Enepret uses engineered baker’s yeast to produce triterpenes, such as squalene, for demanding applications. Historically, squalene is harvested from shark liver oil, an unsustainable environmental source and undesirable, due to the presence of persistent organic pollutants in our marine ecosystems. Through our proprietary strains and downstream processing, we produce >99% pure triterpene oils. We were the first to demonstrate (Tateno et al., 2020) the utility of these synthetic biology-produced triterpenes in an emulsion vaccine adjuvant.

Our technology originated from IP developed at the University of Kentucky, in Dr. Joe Chappell’s lab, which has been prolific in the study of terpenes and their biosynthesis since 1985. Founded in 2017, Enepret continues to build on this with a focus on providing the highest purity triterpenes and adjuvant formulations for pharmaceutical applications, antibody production, and vaccine research and development.

Tateno, M. et al. (2020) “Synthetic Biology-derived triterpenes as efficacious immunomodulating adjuvants.” Scientific Reports. 10: 17090.